This protocol assumes that you have run Meridien.
Once these steps have been completed, perform a restricted refinement.
Based on protocol developed by Zhong Huang and Pawel Penczek
Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW, Shi Y. (2015) “An atomic structure of human γ-secretase.” Nature 525: 212-217. doi: 10.1038/nature14892.