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gpu_isac [2020/07/27 12:39]
fschoenfeld 		gpu_isac [2020/08/03 15:25]
fschoenfeld
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 ===== Overview ===== ===== Overview =====
  
-**ISAC** (Iterative Stable Alignment and Clustering) is a 2D classification algorithm to sort cryo-EM particles into classes depicting the same view of a target protein. It is based around iterations of  +**ISAC** (//Iterative Stable Alignment and Clustering//) is a **2D classification algorithm**. It sorts a given stack of cryo-EM particles into different classes that share the same view of a target protein. ISAC is based around iterations of alternating equal size k-means clustering and repeated 2D alignment routines.
-alternating equal size k-means clustering and repeated 2D alignment routines. +
  
 <note> <note>
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 </note> </note>
  
-**ISAC2** is an improved version of ISAC, and the default tool to produce 2D class averages in the **[[http://sphire.mpg.de/wiki/doku.php?id=downloads:sphire_1_3|SPHIRE]]** ([[https://github.com/cryoem/eman2|git]]) software package and the **[[https://github.com/MPI-Dortmund/transphire|TranSPHIRE]]** automated pipeline for processing cryo-EM data. ISAC2 is a CPU-only implementation that is usually run on a computer cluster.+**ISAC2** is an improved version of ISAC and used by default tool to produce 2D class averages in the **[[http://sphire.mpg.de/wiki/doku.php?id=downloads:sphire_1_3|SPHIRE]]** ([[https://github.com/cryoem/eman2|git]]) software package and the **[[https://github.com/MPI-Dortmund/transphire|TranSPHIRE]]** automated pipeline for processing cryo-EM data. ISAC2 is a CPU-only implementation that was developed to run on a computer cluster.
  
 **GPU ISAC** is designed to run ISAC2 on a single workstation by outsourcing its computationally expensive calculations to any available GPUs. **GPU ISAC** is designed to run ISAC2 on a single workstation by outsourcing its computationally expensive calculations to any available GPUs.
  
 <note important> <note important>
-**Beta version:** The currently available version of GPU ISAC is a beta version. A significantly improved and significantly faster version is being tested right now and will be released shortly.+**Chimera Beta:** The previously distributed GPU ISAC "Chimera" Beta version is no longer supported and we recommend using the current version of GPU ISAC. You can still find the "Chimera" documentation [[https://sphire.mpg.de/wiki/doku.php?id=gpu_isac_chimera|here]], however.
 </note> </note>
  
gpu_isac.txt · Last modified: 2021/05/08 00:41 by shaikh

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